Antimicrobials with excellent oral bioavailability
Levofloxacin

Levofloxacin

High
Excellent
IV-$14/d PO-$3/d

Dosing

General Information

Lower respiratory infection (CAP, HAP), intraabdominal infection

Monitor QTc in patients with increased risk

  • QTc prolongation
  • Dysglycemia
  • CNS toxicity including confusion, psychosis
  • Tendinopathy and rupture
  • GI upset
  • Weakness exacerbation in myasthenia gravis
  • Rash
  • Other QTc prolonging agents
  • Divalent cations - decreased absorption
  • NSAIDs - increase seizure risk
  • Warfarin - increased INR

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7.0

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic