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Antimicrobials
Levofloxacin

Levofloxacin

C difficile risk
High
Oral Bioavailability
Excellent
Cost
IV-$14/d PO-$3/d

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

500-750mg PO/IV daily

Renal

0 - 20 eGFR20 - 50 eGFR50+ eGFR750mg once then 500mg PO/IV q48h750mg PO/IV q48h750mg PO/IV daily

750mg IV/PO load then 500mg q48h

750mg IV load then 500mg daily, may increase if larger flow rate

General Information

Common Usage

Lower respiratory infection (CAP, HAP), intraabdominal infection

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • CNS toxicity including confusion, psychosis

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • Rash

Major Interactions

  • Other QTc prolonging agents

  • Divalent cations - decreased absorption

  • NSAIDs - increase seizure risk

  • Warfarin - increased INR

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7.0

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic