Antimicrobials
Trimethoprim-sulfamethoxazole

Trimethoprim-sulfamethoxazole

Low
Excellent
IV$100/d PO$1/d

Dosing

General Information

Urinary tract infections, susceptible MRSA infections, Stenotrophomonas infections, Pneumocystis jirovecii pneumonia (treatment or prophylaxis)

Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia

Stevens Johnson syndrome/toxic epidermal necrolysis, other rashes, gastrointestinal upset common, bone marrow suppression, hyperkalemia, renal failure, hepatitis, aseptic meningitis

ACEi - increased serum potassium level

Increases amantadine levels

Decreases cyclosporine

Methotrexate- marrow suppression

Increases phenytoin

Increases rifampin

Increases INR with warfarin

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: C

Average serum half life: 10.0

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic