Antimicrobials
Linezolid

Linezolid

Low
Excellent
$190/day

Spectrum of Activity

Dosing

General Information

Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia.

Covers MRSA and VRE

CBC at least once/week

Visual testing for therapy >3mo or if symptoms develop on therapy

  • Myelosuppression (usually with >2weeks therapy)- reversible
  • Peripheral/optic neuropathy with prolonged courses
  • Serotonin syndrome
  • Rash
  • Elevated liver enzymes
  • Lactic acidosis

SSRI and other serotonergics/MAOIs- increased risk of serotonin syndrome

Rifampin decreases linezolid levels

Antimicrobial class: Oxazolidinone

Pregnancy category: C

Average serum half life: 5.0

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic