Antimicrobials with excellent oral bioavailability
Ciprofloxacin

Ciprofloxacin

High
Excellent
IV-$4/d PO-$3/d

Dosing

General Information

Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen, and other sites

Monitor QTc in patients with increased risk

  • QTc prolongation
  • Dysglycemia
  • CNS toxicity including confusion, psychosis
  • Tendinopathy and rupture
  • GI upset
  • Weakness exacerbation in myasthenia gravis
  • Rash
  • Retinal detachment
  •  CYP1A2 inhibitor - multiple interactions possible
  •  QTc prolongation - Increased risk with other agents that prolong QTc
  •  Di- & Trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - decreased absorption
  •  Cyclosporine - increased levels of cyclosporine
  •  Warfarin - increased INR
  •  Methadone - lowered seizure threshold

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4.0

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic