Ciprofloxacin
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis (EGFR)

0 - 10 eGFR

400mg IV q24h

0 - 10 eGFR

500mg PO q24h

10 - 50 eGFR

400mg IV q24h

10 - 50 eGFR

250-500mg PO q12h

50+ eGFR

400mg IV q8-12h

50+ eGFR

500-750mg PO q12h

Intermittent Dialysis

400mg IV or 500mg PO q24h, dose after HD on dialysis days

Continuous Dialysis

400mg IV q12h