Antimicrobials
Cefepime

Cefepime

C difficile risk
High
Oral Bioavailability
N/A
Cost
$60/day

Dosing

2g IV q8-12h

0 - 10 eGFR10 - 30 eGFR30 - 60 eGFR60+ eGFR1g IV q24h2g IV q24h2g IV q12h2g IV q8h

1g IV q24h, dose post-HD on dialysis days

2g IV q8h

General Information

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

  • Allergy (immediate & delayed)

  •  Positive Coombs

  •  Cytopenias

  •  Non-convulsive status epilepticus

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic