Suspected or proven MRSA, coagulase-negative Staphylococcal infections, Enterococcal infections
Collect trough 0-1h before 3rd dose if abnormal/fluctuating renal function.
Target trough 15-20mcg/mL for most serious infections
If trough low, increase dose (do not exceed 2g/dose) OR decrease dosing interval.
If trough >20, increase dosing interval or decrease dose
Red man syndrome (histamine release- slow down infusion), nephrotoxicity, cytopenias, rash including Stevens-Johnson Syndrome, others
Aminoglycosides may potentiate nephrotoxicity
May enhance neuromuscular blockade of NM blocking agents
Careful with concomitant nephrotoxins
Antimicrobial class: glycopeptide
Pregnancy category: C
Average serum half life: 8.0
Biliary penetration: Moderate
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic