Vancomycin IV

Vancomycin IV



General Information

Suspected or proven MRSA, coagulase-negative Staphylococcal infections, Enterococcal infections

Collect trough 0-1h before 3rd dose if abnormal/fluctuating renal function.

Target trough 15-20mcg/mL for most serious infections

If trough low, increase dose (do not exceed 2g/dose) OR decrease dosing interval.

If trough >20, increase dosing interval or decrease dose

Red man syndrome (histamine release- slow down infusion), nephrotoxicity, cytopenias, rash including Stevens-Johnson Syndrome, others

Aminoglycosides may potentiate nephrotoxicity

May enhance neuromuscular blockade of NM blocking agents

Careful with concomitant nephrotoxins

Antimicrobial class: glycopeptide

Pregnancy category: C

Average serum half life: 8.0

Biliary penetration: Moderate

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic