Antimicrobials
Clarithromycin

Clarithromycin

Medium
Moderate
$1/day

Spectrum of Activity

Dosing

General Information

  • CAP
  • Pertussis
  • URTI
  • H. pylor and mycobacterial infections

Monitor QTc in patients with increased risk

  • Neutropenia
  • GI upset
  • Prolongation of QTc interval
  • Drug interactions

CYP450 interactions ++

  • Other QTc prolonging agents
  • Recommend review of pt medications due to high frequency of significant interactions
  • Statins - increased rhabdo
  • CCBs - hypotension, AKI
  • Colchicine - increased bone marrow toxicity
  • Increased anticonvulsant levels
  • Increased tacrolimus levels

Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing

Antimicrobial class: Macrolide

Pregnancy category: C

Average serum half life: 5.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor